The endian select registers (MDEB, MDES) are such that endian information you set in the [Endian] property in the [Operating Modes of CPU] [E1] [E20] [EZ Emulator] category on the Property panel's [Connect Settings] tab (or the [Endian of CPU] property in the [Endian] [Simulator] category on the Property panel's [Connect Settings] tab for the simulator) is written to the register corresponding to the operation mode in which you perform debugging.
When debugging in single-chip mode, you cannot modify the endian select register S (MDES) in the Memory panel, etc. When debugging in the user boot mode, you cannot modify the endian select register B (MDEB) in the Memory panel, etc.